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Fast Dissolving Films- A Novel Approach for Delivery of Domperidone

Fast Dissolving Films- A Novel Approach for Delivery of Domperidone

Fast Dissolving Film of Domperidone
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The book describes the preparation and evaluation of orally fast dissolving film of Domperidone- an anti emetic drug. As Domperidone possess very less water solubility, preparation of rapidly dissolving film is a challenge. Hence, in order to increase the solubility, solid dispersion approach is utilized and it is prepared using beta- cyclodextrin as a carrier. Solid dispersion are prepared in various molar ratio of Drug: Carrier and evaluated. Based on evaluation, the optimized solid dispersion is selected and utilized further for the preparation of films. Suitable film forming polymer was selected from the available polymers i.e. HPMC E3 LV, HPMC E5 LV, HPMC E15 LV and pullulan. PUllulan was found to be suitable for preparation of film. Films are prepared using pullulan and PEG-400 by solvent casting method and evaluated. Factorial design was applied in order to decide the optimized formulation and it was then compared with the films prepared with plain Domperidone. Results showed that films prepared using solid dispersion were better than the films prepared using plain Domperidone. Hence, fast dissolving film of Domperidone was successfully prepared.

Produktdetails

Autor: Pratikkumar Joshi
ISBN-13: 9783659169847
ISBN: 3659169846
Einband: Paperback
Seiten: 120
Gewicht: 195 g
Format: 220x150x7 mm
Sprache: Englisch
Autor: Pratikkumar Joshi, Harsha Patel
Pratikkumar Joshi, Masters in Pharmacy (Pharmaceutics): A.R.College of Pharmacy and G.H.Patel Institute of Pharmacy, Gujarat Technological University, Gujarat.

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Autor: Pratikkumar Joshi
ISBN-13:: 9783659169847
ISBN: 3659169846
Verlag: LAP Lambert Academic Publishing
Gewicht: 195g
Seiten: 120
Sprache: Englisch
Sonstiges: Taschenbuch, 220x150x7 mm