59,00 €*
Formulation and Evaluation of Floating In Situ Gel of Levetiracetam

Formulation and Evaluation of Floating In Situ Gel of Levetiracetam

Geriatric and Paediatric convince Approaches
 Paperback
Sf Print on Demand | Versandkostenfrei
99
The aim of this study was to develop a new intra-gastric oating in situ gelling system for controlled delivery of levetiracetam for the treatment of partial onset seizures.High dose of levetiracetam (750 to 1000 mg) is di cult to incorporate in oating tablets but can easily be given in liquid dosage form. Sodium alginate-based in-situ gelling systems were prepared by dissolving various concentrations of sodium alginate in deionized water, to which drug and calcium carbonate were added. A 32 full factorial design was used for optimization. The concentrations of sodium alginate (X1) and calcium carbonate (X2) were selected as the independent variables.The amount of the drug released after 1 h (Q1) and 6 h (Q6) and 12 h (Q12), viscosity and Floating lag time of the liquid formulation were selected as the dependent variables. The studies indicate that the formulation was effective in providing in vitro release for extended time up to 12 hrs and also convenient for geriatric and paediatric patient and increase drug residency to the GIT.

Produktdetails

Autor: Miteshkumar Patel
ISBN-13: 9783659157646
ISBN: 3659157643
Einband: Paperback
Seiten: 132
Gewicht: 213 g
Format: 220x150x8 mm
Sprache: Englisch
Autor: Miteshkumar Patel, Kanu Patel, Natvarlal Patel
Mr. Miteshkumar Patel has obtained his M. Pharm degree in Pharmaceutics from Shri B. M. Shah college of pharmaceutical education and research, Modasa in 2012 from Gujarat Technological University. He is the author with several articles published in international journals.

Zu diesem Artikel ist noch keine Rezension vorhanden.
Helfen sie anderen Besuchern und verfassen Sie selbst eine Rezension.

 

Rezensionen

Autor: Miteshkumar Patel
ISBN-13:: 9783659157646
ISBN: 3659157643
Verlag: LAP Lambert Academic Publishing
Gewicht: 213g
Seiten: 132
Sprache: Englisch
Sonstiges: Taschenbuch, 220x150x8 mm