128,39 €*
Retroviral Insertion and Oncogene Activation

Retroviral Insertion and Oncogene Activation

 Book
Sf Print on Demand | Versandkostenfrei
99
Retroviral Mutagenesis of Cellular Oncogenes: A Review with Insights into the Mechanisms of Insertional Activation.- Mutagenesis of the Mouse Germline Using Retroviruses.- Insertional Mutagenesis in Mouse Mammary Tumorigenesis.- Feline Leukaemia Virus: Generation of Pathogenic and Oncogenic Variants.- Virus-Host Interactions and the Pathogenesis of Murine and Human Oncogenic Retroviruses.
An integrated retrovirus effectively becomes part of the cellular genome, but with the difference that the virus to a large extent retains control over its own expression through nontranslated sequences in the long terminal repeat (L TR). Some retroviruses also code for nonstructural proteins that further regulate proviral expression. Integration changes the cell genome; it adds viral genes, and in the case of transducing retroviruses also adds cell-derived oncogenes that have been incorporated into the viral genome. Integration can also have consequences for cellular genes. The transcriptional signals in a provirus can activate expression of neighboring cellular genes; the integration even can disrupt and thus inactivate cellular genes. These effects of retroviral genomes take place in cis; they are referred to as insertional mutagenesis and are the subject of this volume. Almost 10 years have passed since W. Hayward, S. Astrin, and their colleagues found that in B cell lymphomas of chickens, induced by avian leukosis virus, transcription of the cellular proto-oncogene myc was upregulated through the integration of a complete or partial provirus in its vicinity. This landmark discovery suggested a mechanism by which retro viruses that do not carry cellular oncogenes in their genome ("nonacute retroviruses") can cause cancer. It contributed the first evidence for the carcinogen potential of oncogenes that are not part of a viral genome.

Mehr zum Thema

    Viren; Viruses; Cancer; diseases; mutagen; oncogenes; oncogenesis; pathogenesis; retroviruses; tumor; tumorigenesis; virology; virus

Produktdetails

Autor: Hsing-Jien Kung
ISBN-13: 9783642765261
ISBN: 3642765262
Einband: Book
Seiten: 196
Gewicht: 304 g
Format: 235x155x10 mm
Sprache: Englisch

Zu diesem Artikel ist noch keine Rezension vorhanden.
Helfen sie anderen Besuchern und verfassen Sie selbst eine Rezension.

 

Rezensionen

Autor: Hsing-Jien Kung
ISBN-13:: 9783642765261
ISBN: 3642765262
Erscheinungsjahr: 06.12.2011
Verlag: Springer Berlin Heidelberg
Gewicht: 304g
Seiten: 196
Sprache: Englisch
Auflage Softcover reprint of the original 1st ed. 1991
Sonstiges: Taschenbuch, 235x155x10 mm