Investigation of Reactions Involving Pentacoordinate Intermediates
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Investigation of Reactions Involving Pentacoordinate Intermediates

The Mechanism of the Wittig Reaction
 Book
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ISBN-13:
9783642320446
Einband:
Book
Erscheinungsdatum:
01.02.2013
Seiten:
231
Autor:
Peter A. Byrne
Gewicht:
501 g
Format:
244x161x20 mm
Serie:
Springer Theses
Sprache:
Englisch
Beschreibung:

Although the Wittig reaction was first discovered in 1953, its reaction mechanism has never been definitively settled. This book shows conclusively that for [2+2] cycloadditions all Wittig reactions occur by the same irreversible mechanism.
Although the Wittig reaction was first discovered in 1953, its reaction mechanism has never been definitively settled. This book shows conclusively that for [2+2] cycloadditions all Wittig reactions occur by the same irreversible mechanism.
Introduction to the Wittig reaction & discussion of the mechanism.- Wittig reactions of aldehydes bearing a beta-heteroatom substituent.- A convenient chromatography-free method for the purification of alkenes produced in the Wittig reaction.- Experimental.
In this thesis, the author outlines the discovery of an effect common to representative examples of all Li salt-free Wittig Reactions. The implications of such a universally applicable effect are that all such Wittig reactions occur through the same mechanism. Although the Wittig reaction was first discovered in 1953, its reaction mechanism has never been definitively settled with many different variants proposed and disproved. The work in this thesis shows conclusively that for [2+2] cycloadditions all Wittig reactions occur by the same irreversible mechanism. In addition, the author also describes a new chromatography-free method for the removal of phosphine oxide from the alkene crude product of the Wittig reaction. The work in this thesis has led to several publications in high-profile journals.