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Chemokines and Skin

Chemokines and Skin

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Chemokines: Attraction of dendritic cells and role in tumor immunobiology.- Chemokine receptors.- Regulation of gene expression of chemokines and their receptors.- Chemokines and T lymphocytes.- Chemokines and mast cells.- Chemokines and eosinophils.- CXC-chemokines - autocrine growth factors for melanoma and epidermoid carcinoma cells.- Expression of chemokines in dermatoses.
The accumulation of white blood cells is a hallmark of inflammation. The penetra tion through the vessel walls and the infiltration around the inflammatory stimulus is a complex process which involves active adherence and directed migration of the inflammatory cells. Chemotactic factors stimulate both adherence and migration. Technical tools such as the Boyden chamber [1] made it possible to study leukocyte migration in vitro. This technique allows differentiation between migration direct ed towards a chemotactic stimulus and non-directed migration. Until a decade ago only two naturally occurring molecules had been clearly iden tified as potent chemotactic attractants of neutrophilic granulocytes. They were the split product of the fifth complement component C5a [2] and the arachidonic acid metabolite leukotriene B4 [3]. In 1986, a novel human monocyte-derived chemo taxin attracting neutrophilic granulocytes with a similar potency was found [4]. This report was quickly confirmed by several groups [5-8]. The new factor was purified, cloned and sequenced [9, 10]. The term "interleukin 8" (IL-8) replaced the various names proposed previously [4-8]. Sequence data revealed that IL-8 belonged to a large family of chemotactic cytokines, now called "chemokines" [11]. Four subfamilies were distinguished on the basis of the number and position of the first cysteine residues. They are desig nated accordingly as C, CC, CXC and CX C chemokines [11-13]. The number of 3 human chemokines identified so far is close to 40 [11-13].

Mehr zum Thema

    Chemokine; Biology; Cells; Dermatose; diseases; growth; growth factor; Inflammation; Lymphocytes; melanoma; molecular biology; Research; tumor

Produktdetails

Autor: Kownatzki
ISBN-13: 9783034897976
ISBN: 3034897979
Einband: Book
Seiten: 156
Gewicht: 280 g
Format: 244x170x8 mm
Sprache: Englisch
Editiert von: Kownatzki, Norgauer
InhaltsangabeChemokines: Attraction of dendritic cells and role in tumor immunobiology.- Chemokine receptors.- Regulation of gene expression of chemokines and their receptors.- Chemokines and T lymphocytes.- Chemokines and mast cells.- Chemokines and eosinophils.- CXC-chemokines - autocrine growth factors for melanoma and epidermoid carcinoma cells.- Expression of chemokines in dermatoses.

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Autor: Kownatzki
ISBN-13:: 9783034897976
ISBN: 3034897979
Erscheinungsjahr: 13.10.2012
Verlag: Birkhäuser Basel
Gewicht: 280g
Seiten: 156
Sprache: Englisch
Auflage Softcover reprint of the original 1st ed. 1998
Sonstiges: Taschenbuch, 244x170x8 mm