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Vascular Adhesion Molecules and Inflammation

Vascular Adhesion Molecules and Inflammation

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How early studies of inflammation led to our current views on the roles of vascular adhesion molecules.- Adhesion of leukocytes from flow: The selectins and their ligands.- Co-operative signaling between leukocytes and endothelium mediating firm attachment.- Production and presentation of chemokines by endothelial cells.- Platelet-activating factor: A signaling molecule for leukocyte adhesion.- Tight junctions and adherens junctions in endothelial cells: Structure and regulation.- The role of PECAM in leukocyte emigration.- Selective lymphocyte migration into secondary lymphoid rrgans and inflamed tissues.- Oxidation-reduction sensitive regulation of vascular inflammatory gene expression.- Quantification and imaging of vascular adhesion molecule expression in inflammatory diseases in vivo.- Leukocyte adhesion and activation in xenografts.- Control of leukocyte adhesion and activation in ischemia-reperfusion injury.- Control of leukocyte adhesion and activation in atherogenesis.
The book will provide an overview of the roles of vascular adhesion molecules in health and disease, with chapters on their cell biology, followed by chapters reviewing their importance in specific disease processes. Vascular adhesion molecules are vital for the physiological processes of leukocyte trafficking and also critically involved in the enhanced leukocyte emigration that is a key feature of all inflammatory and immune diseases. The book is designed to provide up-to-date, linked reviews of the subject suitable for postgraduate students entering the field or research workers from allied disciplines needing a modern overview.

Mehr zum Thema

    Biology; Cell; cell biology; diseases; Migration; Research

Produktdetails

Autor: Jeremy D. Pearson
ISBN-13: 9783034897532
ISBN: 3034897537
Einband: Book
Seiten: 276
Gewicht: 480 g
Format: 244x170x14 mm
Sprache: Englisch

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Autor: Jeremy D. Pearson
ISBN-13:: 9783034897532
ISBN: 3034897537
Erscheinungsjahr: 01.11.2012
Verlag: Birkhäuser Basel
Gewicht: 480g
Seiten: 276
Sprache: Englisch
Auflage Softcover reprint of the original 1st ed. 1999
Sonstiges: Taschenbuch, 244x170x14 mm