Essential Concepts in Toxicogenomics
-12 %

Essential Concepts in Toxicogenomics

 Previously published in hardcover
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ISBN-13:
9781617376887
Einband:
Previously published in hardcover
Seiten:
300
Autor:
William B. Mattes
Gewicht:
511 g
Format:
235x155x18 mm
Sprache:
Englisch
Beschreibung:

The field of toxicogenomics has been growing quickly. This informative and cutting-edge book collects reviews, opinion pieces and case studies from this dynamic field with a focus on its application to pharmaceuticals.
Inhaltsangabe- Toxicogenomics and Classical Toxicology: How to Improve Prediction and Mechanistic Understanding of Human Toxicity Donna L. Mendrick Use of Traditional Endpoints and Gene Dysregulation to Understand Mechanisms of Toxicity: Toxicogenomics in Mechanistic Toxicology Wayne R. Buck, Jeffrey F. Waring, Eric A. Blomme. Quality Control of Microarray Assays for Toxicogenomic and In Vitro Diagnostic Applications Karol L. Thompson and Joseph Hackett Role of Statistics in Toxicogenomics Michael Elashoff Predictive Toxicogenomics in Preclinical Discovery Scott A. Barros and Rory B. Martin In Vivo Predictive Toxicogenomics Mark W Porter Bioinformatics: Databasing and Gene Annotation Lyle D. Burgoon and Timothy R. Zacharewski Microarray Probe Mapping and Annotation in CrossSpecies Comparative Toxicogenomics John N Calley, William B Mattes, and Timothy Ryan Toxicogenomics in Biomarker Discovery Marc F. DeCristofaro and Kellye K. Daniels From Pharmacogenomics to Translational Biomarkers Donna L. Mendrick Public Consortium Efforts in Toxicogenomics William B. Mattes Applications of Toxicogenomics to Nonclinical Drug Development Regulatory Science Considerations Frank D. Sistare and Joseph J. DeGeorge
Toxicogenomics and Classical Toxicology: How to Improve Prediction and Mechanistic Understanding of Human Toxicity
Donna L. Mendrick Use of Traditional Endpoints and Gene Dysregulation to Understand Mechanisms of Toxicity: Toxicogenomics in Mechanistic Toxicology
Wayne R. Buck, Jeffrey F. Waring, Eric A. Blomme. Quality Control of Microarray Assays for Toxicogenomic and In Vitro Diagnostic Applications
Karol L. Thompson and Joseph Hackett Role of Statistics in Toxicogenomics
Michael Elashoff Predictive Toxicogenomics in Preclinical Discovery
Scott A. Barros and Rory B. Martin In Vivo Predictive Toxicogenomics
Mark W Porter Bioinformatics: Databasing and Gene Annotation
Lyle D. Burgoon and Timothy R. Zacharewski Microarray Probe Mapping and Annotation in Cross-Species Comparative Toxicogenomics
John N Calley, William B Mattes, and Timothy Ryan Toxicogenomics in Biomarker Discovery
Marc F. DeCristofaro and Kellye K. Daniels From Pharmacogenomics to Translational Biomarkers
Donna L. Mendrick Public Consortium Efforts in Toxicogenomics
William B. Mattes Applications of Toxicogenomics to Nonclinical Drug Development - Regulatory Science Considerations
Frank D. Sistare and Joseph J. DeGeorge
The field of toxicogenomics has been growing quickly, yet with rapid growth comes the need to periodically reflect on the nature of the field. Essential Concepts in Toxicogenomics collects reviews, opinion pieces and case studies from the leading experts in this dynamic field with a focus on its application to pharmaceuticals. Topics covered include issues that affect the quality of toxicogenomics experiments, statistical approaches to their data analysis, the use of such data to build toxicogenomic models, and the utilization of genomics to identify biomarkers within the preclinical and clinical arenas. Although not in the standard Methods in Molecular Biology(TM) series format, this volume retains the practicality and usefulness of the highly successful series.
Informative and cutting-edge, Essential Concepts in Toxicogenomics is an ideal resource for pharmaceutical companies, chemical manufacturers, toxicologists, and all who must keep up-to-date on progress in this vital and important field.