Transgenic and Knockout Models of Neuropsychiatric Disorders
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Transgenic and Knockout Models of Neuropsychiatric Disorders

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ISBN-13:
9781617376078
Einband:
Taschenbuch
Seiten:
296
Autor:
Gene S. Fisch
Gewicht:
461 g
Format:
229x152x mm
Serie:
Contemporary Clinical Neuroscience
Sprache:
Englisch
Beschreibung:
Neuroscientists are now establishing meaningful genotype-phenotype relationships for complex neurobehavioral and neuropsychiatric disorders and even creating animal models for these dysfunctions. These developments have made it imperative to know when such transgenic and knockout models are valid for the human disorders they represent. In Transgenic and Knockout Models of Neuropsychiatric Disorders, a panel of leading researchers comprehensively assesses how and whether the genetic abnormalities produced from these models manifest the neuropsychiatric disorders to which they correspond. The authors focus on transgenic and knockout models of neurocognitive dysfunction and neuropsychiatric dysfunction. The discussion of neurobiological problems covers mental retardation, polyglutamate, as well as speech disorders, and disorders that involve cognitive, social, speech, and language dysfunction. The neuropsychiatric dysfunctions examined include psychosis and schizophrenia, anxiety, depression, and bipolar disorder. Timely introductory articles debate the alleged continuity of species of human and infrahuman behavior (Darwin), the utility of infrahuman animals in understanding human behavior and psychiatric disease, and the suitability of nonhuman models of complex neuropsychiatric dysfunctions involving language. Comprehensive and systematic, Transgenic and Knockout Models of Neuropsychiatric Disorders offers a clear assessment of whether genetic abnormalities produced from infrahuman models manifest the neuropsychiatric disorders to which they correspond in humans and how best they may be used to carry out successful research today.
Introduction and Overview
Transgenic and Knockout Models of Psychiatric Disorders: Introduction, History, and Assessment
Gene S. Fisch
Transgenic Mouse Models and Human Psychiatric Disease
Jonathan Flint
Transgenic and Knockout Mouse Models: The Problem of Language
Linda J. Hayes and Diana Delgado
If Only They Could Talk: Genetic Mouse Models for Psychiatric Disorders
Trevor Humby and Lawrence Wilkinson
Transgenic and Knockout Models of Neurocognitive Dysfunction
Spinocerebellar Ataxia Type 1: Lessons From Modeling a Movement Disease in Mice
Harry T. Orr
Mouse Models of Hereditary Mental Retardation
Hans Welzl, Patrizia D'Adamo, David P. Wolfer, and Hans-Peter Lipp
How Can Studies of Animals Help to Uncover the Roles of Genes Implicated in Human Speech and Language Disorders?
Simon E. Fisher Animal Models of Autism: Proposed Behavioral Paradigms and Biological Studies
Thomas Bourgeron, Stéphane Jamain, and Sylvie Granon
Transgenic and Knockout Models of Neuropsychiatric Dysfunction
Genetic Mouse Models of Psychiatric Disorders: Advantages, Limitations, and Challenges
Joseph A. Gogos and Maria Karayiorgou
Animal Models of Psychosis
Stephen I. Deutsch, Katrice Long, Richard B. Rosse, Yousef Tizabi, Ronit Weizman, Judy Eller, and John Mastropaolo
Animal Models of Anxiety: The Ethological Perspective
Robert Gerlai, Robert Blanchard, and Caroline Blanchard
Modeling Human Anxiety and Depression in Mutant Mice
Andrew Holmes and John F. Cryan
Mutant Mouse Models of Bipolar Disorder: Are There Any?
Anneloes Dirks, Lucianne Groenink, and Berend Olivier
Index
Neuroscientists are now establishing meaningful genotype-phenotype relationships for complex neurobehavioral and neuropsychiatric disorders and even creating animal models for these dysfunctions. These developments have made it imperative to know when such transgenic and knockout models are valid for the human disorders they represent. In Transgenic and Knockout Models of Neuropsychiatric Disorders, a panel of leading researchers comprehensively assesses how and whether the genetic abnormalities produced from these models manifest the neuropsychiatric disorders to which they correspond. The authors focus on transgenic and knockout models of neurocognitive dysfunction and neuropsychiatric dysfunction. The discussion of neurobiological problems covers mental retardation, polyglutamate, as well as speech disorders, and disorders that involve cognitive, social, speech, and language dysfunction. The neuropsychiatric dysfunctions examined include psychosis and schizophrenia, anxiety, depression, and bipolar disorder. Timely introductory articles debate the alleged continuity of species of human and infrahuman behavior (Darwin), the utility of infrahuman animals in understanding human behavior and psychiatric disease, and the suitability of nonhuman models of complex neuropsychiatric dysfunctions involving language. Comprehensive and systematic, Transgenic and Knockout Models of Neuropsychiatric Disorders offers a clear assessment of whether genetic abnormalities produced from infrahuman models manifest the neuropsychiatric disorders to which they correspond in humans and how best they may be used to carry out successful research today. In this up-to-date survey and critical assessment of transgenic and knockout models in neuropsychiatry and behavior, a panel of leading researchers comprehensively assesses how and whether the genetic abnormalities produced from these models manifest the neuropsychiatric disorders to which they correspond. The authors focus on transgenic and knockout models of neurocognitive dysfunction and neuropsychiatric dysfunction. The discussion of neurobiological problems covers mental retardation, polyglutamate, and speech disorders, as well as disorders that involve cognitive, social, speech, and language dysfunction. The neuropsychiatric dysfunctions examined include psychosis and schizophrenia, anxiety, depression, and bipolar disorder.