Bone Metastasis
-12 %

Bone Metastasis

 Previously published in hardcover
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ISBN-13:
9781617375453
Einband:
Previously published in hardcover
Erscheinungsdatum:
19.11.2010
Seiten:
360
Autor:
Shafaat A. Rabbani
Gewicht:
756 g
Format:
254x178x22 mm
Sprache:
Englisch
Beschreibung:

Bone metastasis occurs in 60 to 85% of all breast, prostate, and lung cancer patients and is responsible for increasing morbidity. In Bone Metastasis: Experimental and Clinical Therapeutics, leading bone metastasis experts from around the world explain the molecular underpinnings of the process, review current treatment approaches, and outline future therapeutic strategies. On the basic science side, the authors illuminate the role of various autocrine, paracrine, and immunological factors involved in the progression and establishment of bone metastases, highlighting the physiological processes that lead to bone degradation, pain, angiogenesis, and dysregulation of bone turnover. On the therapeutic side, the authors discuss various strategies that appear to have promise and are currently deployed in treatment or at the experimental stage. They show how the treatment of bone metastases may need to be individualized through a combination of surgical, radiation, and/or pharmacological maneuvers. Their analysis of various pharmacogenomic parameters and tissue environmental factors sets the stage for progress beyond the current standards of using radiation and/or bisphosphonates for palliation. Stateoftheart and innovative, Bone Metastasis: Experimental and Clinical Therapeutics elucidates for all those involvedwhether in research or clinical treatment of boneseeking cancersthe biological processes and therapeutic advances that are already generating significant improvement in the cancer clinic.
Part I. Fundamental Concepts
Overview
Sadmeet Singh and Gurmit Singh
Parathyroid Hormone-Related Peptide and Malignancy
David Goltzman
Vitamin D and Vitamin D Analogs in Cancer Progression and Metastasis
Richard Kremer and Shafaat A. Rabbani
Role of TGF-b and IGF in Tumor Progression and Bone Metastases
Erin Giles and Gurmit Singh
Biologic and Therapeutic Implications of Osteomimicry and Epithelial-Mesenchymal Transition in Prostate Cancer
Wen-Chin Huang, Valerie Odero-Marah, and Leland W. K. Chung
Roles of Immune-Cell-Derived Matrix Metalloproteinases in Tumor Growth and Metastasis
Kristina A. Szabo and Gurmit Singh
Contribution of Osteopontin to the Development of Bone Metastasis
Alison L. Allan, Alan B. Tuck, Vivien H. C. Bramwell, Theodore A. Vandenberg, Eric W. Winquist, and Ann F. Chambers
Role of Interleukin-11 in Osteolytic Bone Metastasis
Ryan R. Simon, Martin K. Butcher, and Stephen G. Shaughnessy
Cell Adhesion Molecules in Tumor Metastasis
Sujata Persad and Gurmit Singh
PTHrP and Cancer: Prostate and Lung
Leonard J. Deftos, D. W. Burton, and Randolph H. Hastings
Antithrombotics in Tumor Growth and Metastasis
Shaker A. Mousa
Part II. Therapeutic Strategies
Challenges and Strategies in the Analysis of Multiple Events in Oncology
Pierre P. Major and Richard J. Cook
Integrins: Novel Targets for the Treatment of Bone Metastasis
Graham C. Parry, Fernando Doñate, Marian L. Plunkett, David E. Shaw, Steven Pirie-Shepherd, and Andrew P. Mazar
Bone Metastasis and Pathological Fractures: Bone Tissue Engineering as a Novel Therapy
Laurie A. McDuffee, Nigel Colterjohn, and Gurmit Singh Role of Photodynamic Therapy for Bone Metastasis
Shane Burch and Albert J. M. Yee
Docetaxel for Metastatic Cancer and Its Rolein Combination Therapies for Advanced Prostate Cancer
Ellen K. Wasan, Martin Gleave, Karen Fang, Kim Chi, Gwyn Bebb, Lincoln Edwards, and Marcel B. Bally
Use of Tetracyclines for Bone Metastases
Eric Seidlitz, Zeina Saikali, and Gurmit Singh
Role of Bisphosphonates in Skeletal Metastases
Arif Hussain and Fred Saad
Radiation Treatment of Bone Metastases
Edward Chow, Jackson Wu, and Elizabeth Toni Barnes
Index
A state-of-the-art review of the molecular underpinnings of bone-seeking cancers, current treatment approaches for them, and future therapeutic strategies. The authors illuminate the role of various autocrine, paracrine, and immunological factors involved in the progression and establishment of bone metastases, highlighting the physiological processes that lead to bone degradation, pain, angiogenesis, and dysregulation of bone turnover. They also discuss the various strategies that appear to have promise and are currently deployed in treatment or are at the experimental stage. Bone metastasis occurs in 60 to 85% of all breast, prostate, and lung cancer patients and is responsible for increasing morbidity. In Bone Metastasis: Experimental and Clinical Therapeutics, leading bone metastasis experts from around the world explain the molecular underpinnings of the process, review current treatment approaches, and outline future therapeutic strategies. On the basic science side, the authors illuminate the role of various autocrine, paracrine, and immunological factors involved in the progression and establishment of bone metastases, highlighting the physiological processes that lead to bone degradation, pain, angiogenesis, and dysregulation of bone turnover. On the therapeutic side, the authors discuss various strategies that appear to have promise and are currently deployed in treatment or at the experimental stage. They show how the treatment of bone metastases may need to be individualized through a combination of surgical, radiation, and/or pharmacological maneuvers. Their analysis of various pharmacogenomic parameters and tissue environmental factors sets the stage for progress beyond the current standards of using radiation and/or bisphosphonates for palliation. State-of-the-art and innovative, Bone Metastasis: Experimental and Clinical Therapeutics elucidates for all those involved-whether in research or clinical treatment of bone-seeking cancers-the biological processes and therapeutic advances that are already generating significant improvement in the cancer clinic.