Hormonal Carcinogenesis II
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Hormonal Carcinogenesis II

Proceedings of the Second International Symposium
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Jan-Ake Gustafsson
811 g
233x154x35 mm

Springer Book Archives
Introductions.- Introductory Remarks.- Opening Address Important Questions in Women's Health Research: Determining the Influence of Hormones on Health.- Symposium Presentations Mammary Carcinogenesis: A Unifying Hypothesis.- Regulation of Cytochrome P-450 and Carcinogenesis: Peroxisome Proliferator-Activated Receptor and Dioxin Receptor.- State Of The Art Lectures.- 1 Cell Cycle and Cell Proliferation.- 2 Role of a Cell Cycle Regulator in Hereditary and Sporadic Cancers.- 3 Molecular Cytogenetics of Solid Tumor Progression.- 4 Nucleocytoplasmic Shuttling of Estrogen Receptors Is Blocked by "Pure Antiestrogens".- I. Epidemiology: Hormonal Cancers.- Causality in Hormone Associated Human Cancers.- 5 Breast Cancer Incidence in Women Exposed to Estrogen and Estrogen-Progestin Replacement Therapy.- 6 Breast Cancer Trends in Women in Sweden, the UK, and the USA in Relation to Their Past Use of Oral Contraceptives.- 7 Gene Expression in Familial Breast Cancer: A Genetic-Epidemiology Study of Premenopausal, Bilateral Breast Cancer.- 2. Breast/Mammary Gland.- The Importance of Human Breast Development in Mammary Carcinogenesis.- 8 Breast Susceptibility to Carcinogenesis.- 9 Hormones, Growth Factors and Gene Expression in Preneoplasias of the Mouse Mammary Gland.- 10 Pathogenesis of Ductal and Lobular Progestin-Induced Mammary Carcinomas in BALB/c Mice.- 3. Endometrium/Uterus.- 11 Is the hsp90 Connection Between Steroid Receptors and Immunosuppressant Binding Immunophilins Involved in the Control of Gene Transcription and Cell Growth?.- 12 Expression and Regulation of 17?-Hydroxysteroid Dehydrogenase Type 1 in Steroidogenic Cells and Estrogen Target Tissues.- Growth Factors in Endometrial Cancer.- 4. Kidney.- 13 Introduction Estrogens and Genitourinary Cancers of Syrian Hamsters.- 14 Interstitial Cell Origin of Estrogen-Induced Kidney Tumors in the Syrian Golden Hamster.- 15 Effects of Estrogens on Microtubule Assembly: Significance for Aneuploidy.- 16 Estrogen Carcinogenesis: A Sequential, Epi-Genotoxic, Multi-Stage Process.- 5. Liver.- Role of Estrogens in Liver Carcinogenesis.- 17 Hormonal Regulation of Hepatic Cell Proliferation and Apoptosis: Implications for Carcinogenesis.- 18 Mechanisms of Tamoxifen-Induced Genotoxicity and Carcinogenicity.- 19 Regulation of Growth-Associated Nuclear Transcription Factors During Growth Hormone-Regulated, Sex Differentiated Rat Liver Carcinogenesis.- 6. Prostate.- 20 Isolation of Differentially Expressed cDNAs from Prostate Cancer Cell Lines Using Differential Display PCR: Identification of an Androgen-Regulated Gene.- 21 Progression of LNCaP Human Prostate Carcinoma Cells: Androgen Receptor Activity and c-myc Gene.- 22 Regulation of Prostatic Growth and Gene Expression: Role of Stroma.- Concluding Remarks.- 23 Sex Hormones and Neoplastic Transformation.- CLINICAL FORUM: Risk and Benefits of Hormone Replacement Therapy and Oral Contraceptive Use.- Therapeutic Implications of Hormone Replacement Therapy and Oral Contraceptives.- 24 Postmenopausal Estrogen-Progestin Therapy in Relation to Cancers of the Endometrium and Breast.- 25 The Use of Hormone Replacement Therapy in Women Previously Treated for Breast Cancer.- 26 Cardioprotection by Hormone Replacement Therapy.- 27 Risk and Benefits of Oral Contraceptives.- 28 Oral Contraceptives and the Risk of Breast and Cervical Cancer.- Communications Session I. Epidemiology, Human Studies.- Some Aspects of Breast Cancer Epidemiology.- Risk of Breast Cancer Associated with Induced Abortion.- Family History of Breast Cancer as a Modifier of Other Risk Factors.- Oral Contraceptive Use and Reproductive Risk Factors for Breast Cancer: A Comparison of Results among Black and White Women.- Patterns of Cancer Mortality in Women Who Had Used Sex Steroid Hormones under Age 60.- Progestogen Use and Risk of Breast Cancer.- Five-Year Survival of Women with Breast Cancer According to Prior Use of Oral Contraceptives.- Plasma Prolactin and IGF-1 Levels in Young, Hea
For those of us who have labored in the field of hormonal carcinogenesis, it has been most gratifying to see its rapid growth and increasing relevance in recent years. Although many factors and forces have contributed to this phenomenon, a few appear particularly significant. Perhaps foremost is the realization that two of the most prevalent cancers which afflict women and men; that is, breast and prostate, have essential hormonal component(s) to their etiologies. This should not surprise us since the high frequency of these cancers in human populations has to date not been attributed to any exogenous physical, environmental, or dietary factor(s). A similar argument may be applied to other less prevalent but equally important cancers including ovarian, endometrial, testicular, cervico vaginal, pituitary, thyroid, and sex hormone-associated hepatic neoplasms. The Office of Research on Women's Health and many women's interest groups have been instrumental in fostering research and public awareness on women's cancers. Similar concern is beginning to emerge for solely male cancers by other groups. To illustrate an example of the potential pervasive role of hormones in the human, particularly sex hormones, Figure I depicts the endogenous and known exogenous exposures to estrogens and progestins during a woman's lifetime, which may contribute to increased risk for hormonally-associated cancers . . = iii M. A. P. _ GI en 2 PoOlmenopauoal ~ EstrogDn ~ Proge. tln GI en J Ovulatory _ 2 Cyel. iii W DES EIP Menotr". 1 Ol,order.