Inflammation in the Pathogenesis of Chronic Diseases
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Inflammation in the Pathogenesis of Chronic Diseases

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ISBN-13:
9781402056888
Einband:
Ebook
Seiten:
324
Serie:
42, Subcellular Biochemistry
eBook Typ:
PDF
eBook Format:
EPUB
Kopierschutz:
1 - PDF Watermark
Sprache:
Englisch
Beschreibung:
"The authors provide exciting and enlightening perspectives on COX-2 and related molecular targets in the future of medicine, including historical perspectives on the discovery and development of aspirin, ibuprofen, and compounds that selectively inhibit COX-2, and the potential for development of new compounds with better efficacy and safety in the 21st century. Specific chapters illuminate the role of inflammatory mechanisms in the pathogenesis of arthritis, cardiovascular disease, cancer, neurodegenerative disease, diabetes mellitus, obesity, and other life-threatening and debilitating conditions. Experts in cardiovascular medicine explore the "COX-2 controversy" regarding adverse effects of some (not all) selective COX-2 inhibitors on the cardiovasculature. Important findings are documented in cancer research showing that selective COX-2 inhibitors have powerful antineoplastic effects against major forms of cancer. A special section explores the current evidence supporting the role of COX-2 and inflammation in the development of Alzheimer's disease and other neurodegenerative conditions and the potential benefit of compounds that modulate COX-2 and other inflammatory cytokines. The final section addresses nutritional modulation of inflammation and the chemopreventive value of anti-inflammatory nutraceutical agents. TOC:From the contents
Preface
Contributors

I. Historical Perspectives
CHAPTER 1. Anti-inflammatory Drugs in the 21st Century
K. D. Rainsford, PhD

II. Inflammatory Mechanisms of Pathogenesis
CHAPTER 2. Nitric oxide synthase and cyclooxygenase interactions in cartilage and meniscus: relationships to joint physiology, arthritis, and tissue repair
J. Brice Weinberg, MD, Beverley Fermor, PhD, Farshid Guilak, PhD
CHAPTER 3. obesity, inflammation, and vascular disease: The Role of the Adipose Tissue as an Endocrine Organ
Paolo Calabro', MD, Edward T. H. Yeh, MD
Chapter 4. COX-2 and THE Inflammogenesis of Cancer
Randall E. Harris, MD, PhD
CHAPTER 5. Role of COX-2 in Inflammatory AND DEGENERATIVE Brain Diseases
Luisa Minghetti, PhD

III. Inflammation and Cardiovascular Disease: the Coxib Controversy
CHAPTER 6. Cardiovascular Effects of the Selective Cyclooxygenase-2 Inhibitors
William B. White, MD
CHAPTER 7. COX-2 inhibitors and Cardiovascular Risk
Daniel J. Salzberg, MD, Matthew R. Weir, MD
CHAPTER 8. A BIOLOGICAL RATIONALE FOR THE CARDIOTOXIC EFFECTS OF ROFECOXIB: COMPARATIVE Analysis with other COX-2 Selective Agents and NSAIDs
R. Preston Mason, PhD, Mary F. Walter, PhD, Charles A. Day, Robert F. Jacob, PhD

IV. COX-2 Blockade in Cancer Prevention and Therapy
CHAPTER 9. Cancer Chemoprevention by COX-2 Blockade: Results of Case Control Studies.
Randall E. Harris, MD, PhD, Joanne Beebe-Donk, Galal A. Alshafie, MD, PhD
CHAPTER 10. Strategies for Colon Cancer Prevention:
Combination of Chemopreventive Agents
Bandaru S. Reddy, DVM, PhD

V. Inflammation and Neurodegenerative Disease
CHAPTER 11. NSAIDs FOR THE Chemoprevention of Alzheimer's Disease
Christine A. Szekely, Ph.D., Terrence Town, Ph.D, Peter P. Zandi,Ph.D
CHAPTER 12. Inflammation in Parkinson's disease:
causative or epiphenomenal?
Andreas Hald, PhD, Johan van Beek, PhD, and Julie Lotharius, PhD

VI. Nutrition, Inflammation and Chronic Disease
CHAPTER 13. NUTRITION, INFLAMMATION, AND CARDIOVASCULAR DISEASE
Michel de Logeril, MD
CHAPTER 14. NUTRITION, INFLAMMATION & bRAIN AGING
Frances C. Lau, PhD, Barbara Shukitt-Hale, PhD, James Joseph, PhD

INDEX
In Inflammation in the Pathogenesis of Chronic Diseases: The COX-2 Controversy, a panel of leading experts chronicles the evidence supporting the roleofinflammationinthepathogenesisofmajorchronicdiseasesanddiscusses the current controversy regarding beneficial versus adverse effects of selective cyclooxygenase-2(COX-2)inhibitors.Expertsinmultipledisciplinesofmedical research provide exciting and enlightening perspectives on COX-2 and related molecular targets in the future of medicine. The book is broadly divided into fivesections. Webeginwithhistoricalperspectivesonthediscoveryanddev- opment of aspirin, ibuprofen, and compounds that selectively inhibit COX-2, including discussion of risk versus benefit and the potential for development of new compounds with better efficacy and safety in the 21st century. This is followed by a section illuminating the role of inflammatory mechanisms in the pathogenesisofarthritis,cardiovasculardisease,cancer,neurodegenerativedisease, diabetes mellitus, obesity, and other life-threatening and debilitating conditions. Specific chapters then explore the COX-2 controversy regarding the potential forpositiveversusnegativeimpactofselectiveCOX-2inhibitorsonthecard- vasculature.Recentfindingssuggestthatcardiovascularriskassociatedwithsome COX-2 inhibitors may not be due to a class effect involving COX-2 inhibition, butratherdependsuponthemolecularstructureofspecificcompoundsthathave independenteffectsunrelatedtoCOX-2andprostaglandinbiosynthesis.Important findingsaredocumentedincancerresearchshowingthatselectiveCOX-2inhibitors havepowerfulantineoplasticeffectsagainstmajorformsofcancer.Aspecialsection exploresthecurrentevidencesupportingtheroleofCOX-2andinflammationinthe development of Alzheimers disease and other neurodegenerative conditions and thepotentialbenefitofcompoundsthatmodulateCOX-2andotherinflammatory cytokines.Thefinalsectionaddressesnutritionalmodulationofinflammationinthe pathogenesisofchronicdiseaseandthechemopreventivevalueofanti-inflammatory nutraceuticalagents.